Prawatt vs. Sklorno
To start this I have not read the book and have only heard the two podcasted episodes.
Here's what I have been thinking of:
The prawatt and sklorno hate each other almost as much as the purist nation hates everyone that's not purist nation. A sklorno craft was destroyed right near prawatt space as I recall.
Their is a very large and extremely fast growing Church of Quentin Barnes. In fact the creterokians are watching said body of people.
Quentin has very recently gone against the will of the prawatt in order to save the lives of his sklorno team mates. Said sklorno team mates are presumably high ranking members of the COQB.
No idea how The Game turns out but the potential for wars between prawatt and sklorno and just sklorno vs the galaxy seems very primed.