Have you ever checked this dude out? http://en.wikipedia.org/wiki/Raymond_Kurzweil
He has a book called "The Singularity Is Near." it has some ideas very consistent with the siglerverse of the future.
Some ideas include: Human lifespan increased to 150 years due to commonplace use of body part replacement therapy. This leaves the question: "Would you propose to your wife if you new you would be with here for approx 125 years?" Or would you ask for a right of renewal after say 25 years..
In essense the singularity is the point in time when computers have the same processing capability as all humanity. At that point any number of wild, crazy things could happen.
Just thought I recognised the ideas of nano tech in your nanobots on the rookie and in some of the James Keeling stories... :)
David Latham (sitedesign) PS: My username kinda sucks for a shout out or story inclusion. How do I change it to just my real name?